I had been on prednisone for a total of 4years for lupus. Since being off of it consistently every time I take it (ex. Medrol pack for bronchitis or prednisone taper for sciatica flares) the lupus seems to go into overdrive. The butterfly rash will begin before the 1st day on it is over, fevers are more severe, bones ache, exhausted, etc. Anyone else experience this?